A Mississippi River cruise has been on my radar for a while, but 2025 might actually be the year I stop talking about it and actually do it. Europe always entices me, with its beautiful landscapes and rich history, but why do I tend to forget about the river cruise experience that’s just a short, single-connection flight away?

American Cruise Lines is rolling out new itineraries, themed sailings and even some impressively long voyages – and they’re pretty tempting. From historic cities to all-inclusive perks, here’s why a Mississippi River cruise with American Cruise Lines is sounding like the move for me this year.

1. It’s Like An All-American Road Trip – But On Water

I’ve been lucky to travel a lot during my time in the travel industry – sailing through the Caribbean islands and Central America, the rivers of Europe and even the Mekong – but somehow, I seem to forget about what’s in my own backyard.

The Mississippi is almost like America’s original highway, shaping the growth, commerce and culture of our nation, and I would imagine cruising it feels like stepping straight into a Mark Twain novel (the good parts, not the questionable hygiene and morals of the time). American Cruise Lines’ Mississippi itineraries cover both the upper (St. Louis to St. Paul) and lower Mississippi (Memphis to New Orleans), plus routes branching into the Ohio and Tennessee Rivers. It seems like such a relaxing yet history-packed way to see the heartland of the country.

And the best part? No fighting for a gas station bathroom or getting lost on Google Maps.

2. The Itineraries Are Next Level In 2025

American Cruise Lines is going all out this year with over a dozen different Mississippi River itineraries.

Want a classic Lower Mississippi sailing? The 8-day Historic Mississippi River Cruise (roundtrip from New Orleans) covers the Deep South’s most iconic ports.

More interested in music? The 9-day Music Cities Cruise from Memphis to Nashville is packed with blues, country and rock history.

And for the Mississippi adventure, there’s the 23-day Complete Mississippi River Cruise, traveling from New Orleans all the way to St. Paul.

Feeling extra adventurous? There’s also a 51-day Great United States Cruise that goes coast to coast. (Yes, 51 days. No, we don’t know if you’d get mail forwarded to the boat.)

3. You Can Choose Between Old-School Charm Or Modern Luxury

American’s fleet gives you options: classic paddlewheelers for that vintage steamboat feel or sleek, modern riverboats with all the high-end touches. Either way, these ships are small and intimate, which means you actually get space to breathe and enjoy the journey.

4. The Onshore Excursions Pretty Cool

American Cruise Lines offers at least one complimentary excursion in every port and a number of other excursions for purchase.

I actually voiced concerns to others who have taken Mississippi cruises over plantation and estate visits. I was worried about the feelings that would arise when visiting some of these places, given our country’s checkered past. But I’ve been assured by many who have sailed with American Cruise Lines that the company does a great job of keeping the focus on history, architecture and the people who shaped these places – the good and the bad.

Here are some of the highlights:

• Manchac Swamp Tour – Hop aboard a covered boat and cruise through the Manchac Swamp, where you’ll get within a few feet of “jumping gators” (yes, really) and spot local wildlife like nutria, herons and egrets. 100 percent Louisiana.
• Houmas House & Gardens – At Houmas House, aka “The Sugar Palace,” you’ll tour 16 rooms filled with rare antiques and Louisiana artwork, stroll through vibrant gardens and learn how this once-thriving sugarcane estate evolved into a thoughtfully preserved landmark.
• A Walk with Mark Twain – Step into the world of Tom Sawyer and Huck Finn as you wander through Mark Twain’s hometown with none other than Mark Twain himself. Richard Garey brings the legendary author to life on this guided stroll through Hannibal, MO, sharing Twain’s own words and observations about the town that shaped his stories. Cap it off with a special performance at the historic Planter’s Barn Theater.
• Grand Ole Opry Show – If you’re gonna do country music, do it right at the Grand Ole Opry. What started as a humble radio show in 1925 is now the most famous stage in country music, showcasing everyone from up-and-coming artists to legendary Opry members.

5. It’s All-Inclusive

Your cruise fare covers meals, drinks, excursions, Wi-Fi, gratuities and a pre-cruise hotel stay. Some 2025 sailings even include free domestic airfare.

So, Am I Doing This?

Honestly, 2025 might just be the year I finally hop on board. With new itineraries, immersive excursions and all-inclusive perks, a Mississippi River cruise is shaping up to be the perfect mix of history and relaxation. And I don’t even need to leave the country.

I’ve sailed through Europe, Asia and the Caribbean, but maybe it’s time to trade castles and canals for gators and gumbo.

Have you ever sailed the Mississippi? I’d love to hear your experience.